Apigenin, as a natural flavonoid compound, is widely present in various fruits, vegetables, and herbal medicines. In recent years, numerous studies have shown that apigenin exhibits significant potential in multiple liver diseases through various pathways such as anti-inflammation, antioxidation, anti-fibrosis, regulation of lipid metabolism, induction of autophagy and apoptosis. This article elaborates on the pharmacological mechanisms and clinical application progress of apigenin in major liver diseases including non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), liver fibrosis, liver cancer, and drug-induced liver injury, and also looks forward to future research directions, aiming to provide a basis for the in-depth exploration of apigenin as a therapeutic drug for liver diseases.

apigenin, non-alcoholic liver disease, alcoholic liver disease, liver fibrosis, liver cancer, oxidative stress, inflammation